Air-Liquid Interface EXposure System

VITO has co-developed a new ‘Air-Liquid Interface (ALI)’ exposure system for lower airway studies.

Current developments are pointing towards the use of this ALI system in real-life settings.

Patent application EP16200571.4

Advantages

Inverted transwell setup overcoming flooding of cell surface with medium
Laminar horizontal flow mimicking flow in lower airways
High deposition
Natural conditioning of flow minimizing lung cell damage

A Novel Exposure System Termed NAVETTA for In Vitro Laminar Flow Electrodeposition of Nanoaerosol and Evaluation of Immune Effects in Human Lung Reporter Cells